Problems of liver cirrhosis
Keywords:
cirrhosis of the liver, clinical symptoms, diagnosis, elimination of causes, treatmentAbstract
The liver is one of the most important organs of the human body, which ensures the purification of blood from toxins. This organ is also actively involved in the digestive system, in the metabolism of carbohydrates, lipids and proteins. It is not surprising that any malfunction of the liver has a negative impact on the whole organism and the life of the patient. Cirrhosis of the liver is a serious disease, as a result of which liver tissue is replaced by connective tissue, and the organ stops performing its function. Cirrhosis of the liver is a chronic progressive disease that can lead to life-threatening consequences. Liver cirrhosis is the final histological stage of a wide range of chronic liver diseases: damage to hepatocytes and protective mechanisms in the liver leads to regeneration and fibrosis. In 2020, The Lancet Gastroenterology & Hepatology published a seminal study of the epidemiological indicators of cirrhosis in 195 countries from 1990 to 2017. He also noted clear geographical fluctuations in the frequency of the pathology. Among the population of the Asia-Pacific region, Central Latin America, and Central and Eastern Europe, the incidence of compensated cirrhosis was found to be 5-6 times higher than in North America, Southeast Asia, and Australia. The incidence of decompensated cirrhosis was highest in the same areas. In most regions, the incidence of compensated and decompensated cirrhosis was higher in men than in women. Cirrhosis of the liver is the result of long-term active hepatitis of various etiologies, so the frequency of liver diseases in different countries is of interest. A large study of 1,016,743 hospitalizations for chronic liver disease in the United States between 2012 and 2016 was conducted. During this period, the frequency of hospitalizations per 100,000 population increased from 3,056 to 3,757, and the financial costs for treating patients increased from 14.9 billion US dollars to 18.8 billion. The average age of patients was 56.8 years in 2012, and 57.8 years in 2016. organized.
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