Peganum harmala Chemical Compounds and Its Pharmacological Effects
Abstract
Peganum harmala plant has been used in traditional Afghan medicine as a medicine in various fields. This plant contains important alkaloids such as Harmalin, Harmin, Harman, etc. The results of previous studies have shown that different concentrations of the mentioned alkaloids are used in the treatment of various diseases, including inhibition of cancer cells, diabetes, control of bacterial and fungal diseases, etc. In this article, after reviewing the definition, history of use, classification of important Peganum harmala alkaloids and their effective chemical compounds, we will further investigate its pharmacological effect as an important medicinal plant. In this review study, the search among the international indexes of Google Scholar, Scopus, Web of Science, Pubmed and Magiran was evaluated without year restrictions and with the keywords of Peganum harmala plant, alkaloid, chemical compounds and pharmacology and related articles. The findings of this research showed that Peganum harmala plant extract is much more effective in preventing the progression of cancer cells than its other pharmacological effects, and a lot of research can be done on it in the future studies in the field of cancer treatment methods. The Peganum harmala plant “Peganum harmala” is considered one of the important medicinal plants that, having valuable alkaloids from the beta-carboline family, produces an effective substance against cancer cells that is effective in the treatment of cancer cells. On the other hand, other pharmacological effects of this plant have caused it to be used in the treatment and control of many diseases such as high blood pressure, diabetes, bacterial and fungal infections, and even Parkinson’s.
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